Predictive value of the perivascular fat attenuation index for MACE in young people suspected of CAD

• Published in: BMC Cardiovascular Disorders 2025, Vol.25 (1)
• Main Authors: Yu, Yani, Shan, Dongkai, Wang, Xi, Liu, Zinuan, Dou, Guanhua, Yang, Junjie, Liu, Yuqi, Chen, Yundai
• Format: Report
• Language: English
• Subjects: Angiography; Teenagers; Youth
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-024-04401-0

Objective The perivascular fat attenuation index (FAI) evaluated by coronary computed tomographic angiography (CCTA) has been reported to have strong prognostic value, but few studies have focused on young people. This study aimed to assess the predictive value of the perivascular FAI in young people suspected of having coronary atherosclerotic disease (CAD). Method A retrospective analysis was performed on adults aged [less than or equal to] 45 years who underwent CCTA due to suspected CAD between 2015 and 2016 and who were followed up for at least 5 years following their visit (n = 503). The perivascular FAI at the proximal segment of the right coronary artery (RCA) was measured and grouped into high FAI and low FAI according to the optimal cut-off value, and the association between a high FAI and major adverse cardiac events (MACE) was evaluated by Cox hazard regression. K-M survival analysis was conducted to assess the prognostic value of the perivascular FAI and improvement over traditional risk factor prediction methods. Results The event-free survival of patients in the high FAI group (FAI[greater than or equal to]-75.2 HU) was significantly lower than that of patients in the low FAI group (FAI