Expression of ryanodine receptor-Ca2+ channel that is regulated by TGF-β

Ryanodine receptors (RyRs) are intracellular channels that release calcium ions from the sarcoplasmic reticulum (SR) in response to either plasma membrane depolarization (in skeletal muscle) or increases in the concentration of intracellular free Ca2+ (in the heart). A gene (beta 4) encoding a ryano...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-07, Vol.257 (5066), p.91-94
Main Authors: GIANNINI, G, CLEMENTI, E, CECI, R, MARZIALI, G, SORRENTINO, V
Format: Article
Language:English
Subjects:
2-Aminopurine - pharmacology
Amino Acid Sequence
Animals
Biological and medical sciences
Calcium - metabolism
Calcium channels
Calcium Channels - drug effects
Calcium Channels - physiology
Cell Line
Cell Membrane - metabolism
Cloning, Molecular
Cycloheximide - pharmacology
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression - drug effects
Mink
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Muscles - physiology
Receptors, Cholinergic - drug effects
Receptors, Cholinergic - genetics
Receptors, Cholinergic - physiology
RNA, Messenger - genetics
RNA, Messenger - metabolism
Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum - metabolism
Sequence Homology, Nucleic Acid
Tetradecanoylphorbol Acetate - pharmacology
Transcription, Genetic - drug effects
Transfection
Transforming Growth Factor beta - pharmacology
Transforming growth factors
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Description
Summary:Ryanodine receptors (RyRs) are intracellular channels that release calcium ions from the sarcoplasmic reticulum (SR) in response to either plasma membrane depolarization (in skeletal muscle) or increases in the concentration of intracellular free Ca2+ (in the heart). A gene (beta 4) encoding a ryanodine receptor (similar to, but distinct from, the muscle RyRs) was identified. The beta 4 gene was expressed in all tissues investigated, with the exception of heart. Treatment of mink lung epithelial cells (Mv1Lu) with transforming growth factor beta (TGF-beta) induced expression of the beta 4 gene together with the release of Ca2+ in response to ryanodine (but not in response to caffeine, the other drug active on muscle RyRs). This ryanodine receptor may be important in the regulation of intracellular Ca2+ homeostasis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1320290