Amoeboid Motility without Actin: Insights into the Molecular Mechanism of Locomotion Using the Major Sperm Protein (MSP) of Nematodes

The amoeboid cell motility of the nematode sperm cytoskeleton was studied in terms of the 14-kD major sperm protein (MSP) rather than on actin. The locomotive system was believed to be produced by the vectorial assembly of MSP filaments and their bundled arrangement into macrofibers with the absence...

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Bibliographic Details
Published in:The Biological bulletin (Lancaster) 1998-06, Vol.194 (3), p.342-344
Main Authors: Stewart, Murray, Roberts, Thomas M., Italiano, Joseph E., King, Karen L., Hammel, Robin, Parathasathy, G., Bullock, Timothy L., McCoy, Airlee J., Kent, Helen, Haaf, Andreas, Neuhaus, David
Format: Article
Language:English
Subjects:
Actin
Actins
Actins - physiology
Adenosine Triphosphate - metabolism
Animals
Brackish
Bundling
Cell membranes
Cell migration
Cell motility
Cells
Dimers
Energy Metabolism
Freshwater
Guanosine Triphosphate - metabolism
Helminth Proteins - physiology
Intermediate filament proteins
Locomotion
Male
Marine
Molecules
Motility
Nematoda
Nematoda - physiology
Nematodes
Polymerization
Roundworms
Space life sciences
Sperm Motility - physiology
Spermatozoa
Structural, Mechanical, and Biological Properties of the Cytoskeleton
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Summary:The amoeboid cell motility of the nematode sperm cytoskeleton was studied in terms of the 14-kD major sperm protein (MSP) rather than on actin. The locomotive system was believed to be produced by the vectorial assembly of MSP filaments and their bundled arrangement into macrofibers with the absence of motor proteins. An in vitro motility system was developed wherein MSP filament arrangement was able to move membrane vesicles. Locomotion required a soluble factor in addition to MSP, membrane vesicles and adenosine triphosphate.
ISSN:0006-3185
1939-8697
DOI:10.2307/1543107