Generalised Pruritus with Prurigo-Like Lesions and Generalised Lymphadenopathy: Could be an Early Diagnostic Clue for Angioimmunoblastic T-Cell Lymphoma and/or Histoplasmosis

Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon systemic lymphoproliferative disorder that comprises approximately one-fifth of all mature peripheral T-cell lymphomas. A broad range of cutaneous manifestations include maculopapular, papulovesicular, erythrodermic, urticarial, plaque-like an...

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Bibliographic Details
Published in:Indian Journal of Dermatology 2023, Vol.68 (6), p.726
Main Authors: Kumar, Shubham, Batra, Anmol, Budania, Anil, Sharma, Deepak, Elhence, Poonam A
Format: Report
Language:English
Subjects:
B cells
Diagnosis
Health aspects
Histoplasmosis
Lymphadenopathy
Non-Hodgkin's lymphomas
Pruritus
T cells
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Summary:Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon systemic lymphoproliferative disorder that comprises approximately one-fifth of all mature peripheral T-cell lymphomas. A broad range of cutaneous manifestations include maculopapular, papulovesicular, erythrodermic, urticarial, plaque-like and nodular, and they are mentioned in 50 of patients and may precede systemic symptoms, which include lymphadenopathy, hepatosplenomegaly and constitutional symptoms. Histoplasmosis is a common granulomatous infection worldwide caused by Histoplasma capsulatum, a dimorphic fungus. Cutaneous manifestations are reported to occur in 10 to 25 of immunosuppressed patients with disseminated histoplasmosis. Generalised pruritus as a presenting feature is rarely described in both of these entities. We report a unique case of AITL with histoplasmosis discovered during paraclinical assessment of generalised pruritus (? neurodermatitis) with prurigo-like lesions and lymphadenopathy.
ISSN:0019-5154
DOI:10.4103/ijd.ijd_974_22