MEIOTIC RECOMBINATION AND CHROMOSOME SEGREGATION IN DROSOPHILA FEMALES

In this review, we describe the pathway for generating meiotic crossovers in Drosophila melanogaster females and how these events ensure the segregation of homologous chromosomes. As appears to be common to meiosis in most organisms, recombination is initiated with a double-strand break (DSB). The i...

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Bibliographic Details
Published in:Annual review of genetics 2002-01, Vol.36 (1), p.205-232
Main Authors: McKim, Kim S, Jang, Janet K, Manheim, Elizabeth A
Format: Article
Language:English
Subjects:
Animals
Chromosomes
crossing over
Crossing over (Genetics)
DNA damage
DNA repair
double-strand break
Drosophila
Drosophila - genetics
Female
Genetic aspects
Genetics
Meiosis
Meiosis - genetics
meiotic recombination
Oogenesis
Recombinant DNA
Recombination, Genetic - genetics
synaptonemal complex
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Summary:In this review, we describe the pathway for generating meiotic crossovers in Drosophila melanogaster females and how these events ensure the segregation of homologous chromosomes. As appears to be common to meiosis in most organisms, recombination is initiated with a double-strand break (DSB). The interesting differences between organisms appear to be associated with what chromosomal events are required for DSBs to form. In Drosophila females, the synaptonemal complex is required for most DSB formation. The repair of these breaks requires several DSB repair genes, some of which are meiosis-specific, and defects at this stage can have effects downstream on oocyte development. This has been suggested to result from a checkpoint-like signaling between the oocyte nucleus and gene products regulating oogenesis. Crossovers result from genetically controlled modifications to the DSB repair pathway. Finally, segregation of chromosomes joined by a chiasma requires a bipolar spindle. At least two kinesin motor proteins are required for the assembly of this bipolar spindle, and while the meiotic spindle lacks traditional centrosomes, some centrosome components are found at the spindle poles.
ISSN:0066-4197
1545-2948
DOI:10.1146/annurev.genet.36.041102.113929