Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis

The recent increase in the incidence of tuberculosis with the emergence of multidrug-resistant (MDR) cases has lead to the search for new drugs that are effective against MDR strains of Mycobacterium tuberculosis and can augment the potential of existing drugs against tuberculosis. In the present st...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2006-11, Vol.13 (9), p.630-635
Main Authors: Bapela, N.B., Lall, N., Fourie, P.B., Franzblau, S.G., Van Rensburg, C.E.J.
Format: Article
Language:English
Subjects:
7-methyljuglone
Antitubercular agents
Antitubercular Agents - isolation & purification
Antitubercular Agents - pharmacology
Antituberculous drug
Cytotoxins - analysis
Drug Combinations
Drug therapy
Drug therapy, Combination
Ebenaceae - chemistry
Isoniazid
Materia medica, Vegetable
Microbial Sensitivity Tests
Mycobacterium tuberculosis - drug effects
Naphthoquinones - isolation & purification
Naphthoquinones - pharmacology
Plant extracts
Plant Roots - chemistry
Radiometry
Rifampicin
Synergy
Tuberculosis
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Summary:The recent increase in the incidence of tuberculosis with the emergence of multidrug-resistant (MDR) cases has lead to the search for new drugs that are effective against MDR strains of Mycobacterium tuberculosis and can augment the potential of existing drugs against tuberculosis. In the present study, we investigated the activities of a naphthoquinone, 7-methyljuglone, isolated from the roots of Euclea natalensis alone and in combination with other antituberculous drugs against extracellular and intracellular M. tuberculosis. Combinations of 7-methyljuglone with isoniazid or rifampicin resulted in a four to six-fold reduction in the minimum inhibitory concentration of each compound. Fractional inhibitory concentration (FIC) indexes obtained were 0.2 and 0.5, respectively, for rifampicin and isoniazid, suggesting a synergistic interaction between 7-methyljuglone and these anti-TB drugs. The ability of 7-methyljuglone to enhance the activity of isoniazid and rifampicin against both extracellular and intracellular organisms suggests that 7-methyljuglone may serve as a promising compound for development as an anti-tuberculous agent.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2006.08.001