Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-

Introduction: Many substances that form methemoglobin (MHb) effectively counter cyanide (CN) toxicity. Although MHb formers are generally applied as treatments for CN poisoning, it has been proposed that a stable, long-acting MHb former could serve as a CN pretreatment. Using this rationale, the 8-a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medical toxicology 2008-09, Vol.4 (3), p.157
Main Authors: Rockwood, Gary A, Duniho, Steven M, Briscoe, Crystal M, Gold, Mark B, Armstrong, Kevin R, Moran, Anita V, Kahler, David W, Baskin, Steven I
Format: Article
Language:English
Subjects:
Complications and side effects
Cyanides
Dosage and administration
Drugs
Health aspects
Hemoglobin
Physiological aspects
Quinoline
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction: Many substances that form methemoglobin (MHb) effectively counter cyanide (CN) toxicity. Although MHb formers are generally applied as treatments for CN poisoning, it has been proposed that a stable, long-acting MHb former could serve as a CN pretreatment. Using this rationale, the 8-aminoquinoline WR242511, a potent long-lasting MHb former in rodents and beagle dogs, was studied in the rhesus monkey for advanced development as a potential CN pretreatment. Methods: In this study, WR242511 was administered intravenously (IV) in 2 female and 4 male rhesus monkeys in doses of 3.5 and/or 7.0 mg/kg; a single male also received WR242511 orally (PO) at 7.0 mg/kg. Health status and MHb levels were monitored following exposure. Results: The selected doses of WR242511, which produced significant methemoglobinemia in beagle dogs in earlier studies conducted elsewhere, produced very little MHb (mean
ISSN:1556-9039