New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines

A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α-acetyl-γ-butyrolactone,...

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Bibliographic Details
Published in:Scholarly Research Exchange 2008-01, Vol.2008, p.1-5
Main Authors: Toche, Raghunath B., Ghotekar, Bhausaheb K., Kazi, Muddassar A., Patil, Shivaraj P., Jachak, Madhukar N.
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Pyrimidines
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Summary:A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α-acetyl-γ-butyrolactone, which upon cyclization using phosphorus oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.
ISSN:1687-8299
1687-8299
DOI:10.3814/2008/434329