Antiobesity and antidiabetic effects of biotransformed blueberry juice in [[KKA.sup.Y]] mice

Aim: Biotransformation of blueberry juice by the Serratia vaccinii bacterium gave rise to adenosine monophosphate- activated protein kinase (AMPK) phosphorylation and glucose uptake in muscle cells and adipocytes, but inhibited adipogenesis. This study investigated the antiobesity and antidiabetic p...

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Bibliographic Details
Published in:International Journal of Obesity 2009-10, Vol.33 (10), p.1166
Main Authors: Brault, A, Vallerand, D, Vuong, T, Harbilas, D, Martineau, LC, Matar, C, Ramassamy, C, Haddad, P.S, Benhaddou-Andaloussi, A
Format: Article
Language:English
Subjects:
Blueberries
Care and treatment
Diabetes
Health aspects
Obesity
Properties
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Summary:Aim: Biotransformation of blueberry juice by the Serratia vaccinii bacterium gave rise to adenosine monophosphate- activated protein kinase (AMPK) phosphorylation and glucose uptake in muscle cells and adipocytes, but inhibited adipogenesis. This study investigated the antiobesity and antidiabetic potential of biotransformed blueb Methods: BJ was incorporated in drinking water of [KKA.sup.Y] mice. Parameters of body weight, food intake, plasma glucose, insulin, leptin, and adiponectin were measured. Before and after therapy, animals were subjected to an oral glucose tolerance test. At the end of treatment, liver, muscle, kidney, epididymal fat pad, abdominal Results: Incorporating BJ in drinking water protected young [KKA.sup.Y] mice from hyperphagia and significantly reduced their weight gain. Moreover, BJ protected young [KKA.sup.Y] mice against the development of glucose intolerance and diabetes mellitus. Chronic BJ administration in obese and diabetic [KKA.sup.Y] mice reduced food Conclusions: This study shows that BJ decreases hyperglycemia in diabetic mice, at least in part by reversing adiponectin levels. BJ also protects young pre-diabetic mice from developing obesity and diabetes. Thus, BJ may represent a novel complementary therapy and a source of novel therapeutic agents against diabetes mellitus. doi:10.1038/ijo.2009.149; published online 18 August 2009 Keywords: antiobesity; antidiabetic; adiponectin; [KKA.sup.Y] mice; blueberry
ISSN:0307-0565