Contraceptive, estrogenic and anti-estrogenic potentials of methanolic root extract of Carpolobia lutea in rodents

Several plants are used in herbal medicine for family planning. Carpolobia lutea is a medicinal plant in South Eastern Nigeria used for family planning. The study was designed to investigate the contraceptive, estrogenic and antiestrogenic potentials of the methanolic root extract of Carpolobia lute...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2011-10, Vol.24 (4), p.445
Main Authors: Ettebong, Ette Okon, Nwafor, Paul Alozie, Ekpo, Memfin, Ajibesin, Kola Kayode
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - anatomy & histology
Birth Weight - drug effects
Body Size - drug effects
Body Weight - drug effects
Chemical properties
Contraceptive Agents - pharmacology
Estradiol - pharmacology
Estrogen Antagonists - pharmacology
Estrogens - pharmacology
Female
Flavonoids - analysis
Health aspects
Lethal Dose 50
Litter Size - drug effects
Male
Materia medica, Vegetable
Methanol
Methanol - chemistry
Mice
Mice, Inbred Strains
Organ Size - drug effects
Ovariectomy
Plant extracts
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - toxicity
Plant Roots - chemistry
Polygalaceae - chemistry
Rats
Rats, Inbred Strains
Saponins - analysis
Uterus - anatomy & histology
Uterus - drug effects
Vagina - drug effects
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Summary:Several plants are used in herbal medicine for family planning. Carpolobia lutea is a medicinal plant in South Eastern Nigeria used for family planning. The study was designed to investigate the contraceptive, estrogenic and antiestrogenic potentials of the methanolic root extract of Carpolobia lutea in both rats and mice. The contraceptive effect of extract (7 - 21mg/kg) administered by intraperitoneal route for four days in divided doses was tested in mice and rats. Sexually-active males were introduced on day 5 at the ratio of 3F:1M and kept with these females till the end of the experiment. Investigations on the estrogenic and antiestrogenic property of the extract (7-21mg/kg) were done in immature rats that had undergone surgical removal of both ovaries. The effects of the extract (vaginal opening, vaginal cornification, uterine wet weight) were compared with 17-beta-estradiol (0.1µg/rat/day) as standard drug. Twenty-four hours later, the animals were sacrificed following the last dose and the weights of uterus, kidney, liver and small intestine were recorded. The extract prevented conception in both mice and rats for two gestational periods. Significant changes (p
ISSN:1011-601X