Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells

The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell li...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2012-07, Vol.25 (3), p.645
Main Authors: Lee, Yang Kok, Lay, Lam Kit, Mahsufi, Mansor Sharif, Guan, Teoh Siang, Elumalai, Sunderasan, Thong, Ong Ming
Format: Article
Language:English
Subjects:
Animals
Artemia - drug effects
Breast
Breast - cytology
Breast - drug effects
Cell Line, Tumor
Cell proliferation
Cell Proliferation - drug effects
Chemical properties
Epithelial cells
Epithelial Cells - drug effects
Female
Growth
Health aspects
Hevea - chemistry
Humans
Latex - pharmacology
Latex - toxicity
Rubber trees
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Summary:The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer-origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test (BSLT), the present results suggest the potential use of the B-serum sub-fractions in cancer treatment.
ISSN:1011-601X