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High-throughput sequential injection assay method for chlorpromazine
This manuscript reports the optimization and validation of a new, rapid, reagent-saving and environmentally-safe method for chlorpromazine assay in pharmaceutical formulations utilizing sequential injection analysis ( SIA ) technique. Despite its benefits over univariate approach, chemometrics has b...
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Published in: | Journal of analytical chemistry (New York, N.Y.) N.Y.), 2013-03, Vol.68 (3), p.233-240 |
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container_title | Journal of analytical chemistry (New York, N.Y.) |
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creator | Naheid, Salih A. Idris, Abubakr M. Elgorashe, Rafea E. E. Altayeb, Mohammed A. H. Alnajjar, Ahmed O. Assubaie, Fahad N. |
description | This manuscript reports the optimization and validation of a new, rapid, reagent-saving and environmentally-safe method for chlorpromazine assay in pharmaceutical formulations utilizing sequential injection analysis (
SIA
) technique. Despite its benefits over univariate approach, chemometrics has been rarely exploited for optimizing SIA methods. Moreover, in those methods, some conditions have not been considered in optimization process. In the current study, more conditions, namely volumes and concentrations of reagents, have been optimized by chemometrics for the first time. A developing oxidation reaction of chlorpromazine by permanganate in acidic media was adopted. A spectrophotometric detection of the reduction of permanganate was applied at 526 nm using miniaturized fiber optic devices. The 2
4
full-factorial design and response surface approaches were exploited for method optimization. The method was validated and realized by a British Pharmacopoeia method. Experimental conditions and analytical aspects of the current SIA method were compared with those of a previous SIA method. Some analytical aspects were comparable while other aspects demonstrated better results from the current method than those from the previous one. The current method is rapid with a sample frequency of 51.4 samples/h. It is also reagent-saving with a total volume of consumed reagents and sample of 260 μL as well as environmental-safety with a total volume of waste production of 1260 μL. The method is therefore efficient for industrial-scale pharmaceutical analysis. |
doi_str_mv | 10.1134/S1061934813030106 |
format | article |
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SIA
) technique. Despite its benefits over univariate approach, chemometrics has been rarely exploited for optimizing SIA methods. Moreover, in those methods, some conditions have not been considered in optimization process. In the current study, more conditions, namely volumes and concentrations of reagents, have been optimized by chemometrics for the first time. A developing oxidation reaction of chlorpromazine by permanganate in acidic media was adopted. A spectrophotometric detection of the reduction of permanganate was applied at 526 nm using miniaturized fiber optic devices. The 2
4
full-factorial design and response surface approaches were exploited for method optimization. The method was validated and realized by a British Pharmacopoeia method. Experimental conditions and analytical aspects of the current SIA method were compared with those of a previous SIA method. Some analytical aspects were comparable while other aspects demonstrated better results from the current method than those from the previous one. The current method is rapid with a sample frequency of 51.4 samples/h. It is also reagent-saving with a total volume of consumed reagents and sample of 260 μL as well as environmental-safety with a total volume of waste production of 1260 μL. The method is therefore efficient for industrial-scale pharmaceutical analysis.</description><identifier>ISSN: 1061-9348</identifier><identifier>EISSN: 1608-3199</identifier><identifier>DOI: 10.1134/S1061934813030106</identifier><language>eng</language><publisher>Dordrecht: SP MAIK Nauka/Interperiodica</publisher><subject>Analytical Chemistry ; Biological assay ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Chlorpromazine ; Identification and classification ; Methods ; Pharmaceutical chemistry</subject><ispartof>Journal of analytical chemistry (New York, N.Y.), 2013-03, Vol.68 (3), p.233-240</ispartof><rights>Pleiades Publishing, Ltd. 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-dc0c13e451d559b97117dd03a55c047c65d7c9e0419773c4402727882e4f99113</citedby><cites>FETCH-LOGICAL-c427t-dc0c13e451d559b97117dd03a55c047c65d7c9e0419773c4402727882e4f99113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Naheid, Salih A.</creatorcontrib><creatorcontrib>Idris, Abubakr M.</creatorcontrib><creatorcontrib>Elgorashe, Rafea E. E.</creatorcontrib><creatorcontrib>Altayeb, Mohammed A. H.</creatorcontrib><creatorcontrib>Alnajjar, Ahmed O.</creatorcontrib><creatorcontrib>Assubaie, Fahad N.</creatorcontrib><title>High-throughput sequential injection assay method for chlorpromazine</title><title>Journal of analytical chemistry (New York, N.Y.)</title><addtitle>J Anal Chem</addtitle><description>This manuscript reports the optimization and validation of a new, rapid, reagent-saving and environmentally-safe method for chlorpromazine assay in pharmaceutical formulations utilizing sequential injection analysis (
SIA
) technique. Despite its benefits over univariate approach, chemometrics has been rarely exploited for optimizing SIA methods. Moreover, in those methods, some conditions have not been considered in optimization process. In the current study, more conditions, namely volumes and concentrations of reagents, have been optimized by chemometrics for the first time. A developing oxidation reaction of chlorpromazine by permanganate in acidic media was adopted. A spectrophotometric detection of the reduction of permanganate was applied at 526 nm using miniaturized fiber optic devices. The 2
4
full-factorial design and response surface approaches were exploited for method optimization. The method was validated and realized by a British Pharmacopoeia method. Experimental conditions and analytical aspects of the current SIA method were compared with those of a previous SIA method. Some analytical aspects were comparable while other aspects demonstrated better results from the current method than those from the previous one. The current method is rapid with a sample frequency of 51.4 samples/h. It is also reagent-saving with a total volume of consumed reagents and sample of 260 μL as well as environmental-safety with a total volume of waste production of 1260 μL. The method is therefore efficient for industrial-scale pharmaceutical analysis.</description><subject>Analytical Chemistry</subject><subject>Biological assay</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chlorpromazine</subject><subject>Identification and classification</subject><subject>Methods</subject><subject>Pharmaceutical chemistry</subject><issn>1061-9348</issn><issn>1608-3199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kc9LwzAUgIMoOKd_gLeCJw-dSZMuzXHMHxsIgtNzielrm9EmM0nB-debMS_DIe-Q9_K-70HyELomeEIIZXcrgqdEUFYQiimOxQkakSkuUkqEOI15bKe7_jm68H6NMRYFmY7Q_UI3bRpaZ4em3Qwh8fA5gAladok2a1BBW5NI7-U26SG0tkpq6xLVdtZtnO3ltzZwic5q2Xm4-j3H6P3x4W2-SJ9fnpbz2XOqWMZDWimsCAWWkyrPxYfghPCqwlTmucKMq2lecSUAMyI4p4oxnPGMF0UGrBYiPnOMbvZzG9lBqU1tg5Oq116VM0opZxnFIlLpEaoBA0521kCt4_UBPznCx6ig1-qocHsgRCbAV2jk4H25XL0esmTPKme9d1CXG6d76bYlweVuc-WfzUUn2zs-sqYBV67t4Ez82X-kH8n0lvk</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Naheid, Salih A.</creator><creator>Idris, Abubakr M.</creator><creator>Elgorashe, Rafea E. E.</creator><creator>Altayeb, Mohammed A. H.</creator><creator>Alnajjar, Ahmed O.</creator><creator>Assubaie, Fahad N.</creator><general>SP MAIK Nauka/Interperiodica</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>20130301</creationdate><title>High-throughput sequential injection assay method for chlorpromazine</title><author>Naheid, Salih A. ; Idris, Abubakr M. ; Elgorashe, Rafea E. E. ; Altayeb, Mohammed A. H. ; Alnajjar, Ahmed O. ; Assubaie, Fahad N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-dc0c13e451d559b97117dd03a55c047c65d7c9e0419773c4402727882e4f99113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analytical Chemistry</topic><topic>Biological assay</topic><topic>Chemical properties</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chlorpromazine</topic><topic>Identification and classification</topic><topic>Methods</topic><topic>Pharmaceutical chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naheid, Salih A.</creatorcontrib><creatorcontrib>Idris, Abubakr M.</creatorcontrib><creatorcontrib>Elgorashe, Rafea E. E.</creatorcontrib><creatorcontrib>Altayeb, Mohammed A. H.</creatorcontrib><creatorcontrib>Alnajjar, Ahmed O.</creatorcontrib><creatorcontrib>Assubaie, Fahad N.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naheid, Salih A.</au><au>Idris, Abubakr M.</au><au>Elgorashe, Rafea E. E.</au><au>Altayeb, Mohammed A. H.</au><au>Alnajjar, Ahmed O.</au><au>Assubaie, Fahad N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-throughput sequential injection assay method for chlorpromazine</atitle><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle><stitle>J Anal Chem</stitle><date>2013-03-01</date><risdate>2013</risdate><volume>68</volume><issue>3</issue><spage>233</spage><epage>240</epage><pages>233-240</pages><issn>1061-9348</issn><eissn>1608-3199</eissn><abstract>This manuscript reports the optimization and validation of a new, rapid, reagent-saving and environmentally-safe method for chlorpromazine assay in pharmaceutical formulations utilizing sequential injection analysis (
SIA
) technique. Despite its benefits over univariate approach, chemometrics has been rarely exploited for optimizing SIA methods. Moreover, in those methods, some conditions have not been considered in optimization process. In the current study, more conditions, namely volumes and concentrations of reagents, have been optimized by chemometrics for the first time. A developing oxidation reaction of chlorpromazine by permanganate in acidic media was adopted. A spectrophotometric detection of the reduction of permanganate was applied at 526 nm using miniaturized fiber optic devices. The 2
4
full-factorial design and response surface approaches were exploited for method optimization. The method was validated and realized by a British Pharmacopoeia method. Experimental conditions and analytical aspects of the current SIA method were compared with those of a previous SIA method. Some analytical aspects were comparable while other aspects demonstrated better results from the current method than those from the previous one. The current method is rapid with a sample frequency of 51.4 samples/h. It is also reagent-saving with a total volume of consumed reagents and sample of 260 μL as well as environmental-safety with a total volume of waste production of 1260 μL. The method is therefore efficient for industrial-scale pharmaceutical analysis.</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S1061934813030106</doi><tpages>8</tpages></addata></record> |
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subjects | Analytical Chemistry Biological assay Chemical properties Chemistry Chemistry and Materials Science Chlorpromazine Identification and classification Methods Pharmaceutical chemistry |
title | High-throughput sequential injection assay method for chlorpromazine |
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