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Development of chromatographic and electrophoretic methods for determining vinblastine in blood plasma and prostate gland tissue
Two methods have been developed for determining antitumor drug vinblastine in blood plasma and prostate gland tissue by high performance liquid chromatography ( HPLC ) and capillary electrophoresis ( CE ) with detection at 214 nm. The lower limit of quantitative determination (15 ng/mL) was achieved...
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| Published in: | Journal of analytical chemistry (New York, N.Y.) N.Y.), 2013-03, Vol.68 (3), p.265-271 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c427t-3f872703fb35f59696a487e33d10e35b0219c285e7968f1ceab9ff664a8c0bcd3 |
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| cites | cdi_FETCH-LOGICAL-c427t-3f872703fb35f59696a487e33d10e35b0219c285e7968f1ceab9ff664a8c0bcd3 |
| container_end_page | 271 |
| container_issue | 3 |
| container_start_page | 265 |
| container_title | Journal of analytical chemistry (New York, N.Y.) |
| container_volume | 68 |
| creator | Sidorova, A. A. Yaroshenko, D. V. Murashko, E. A. Grigor’ev, A. V. |
| description | Two methods have been developed for determining antitumor drug vinblastine in blood plasma and prostate gland tissue by high performance liquid chromatography (
HPLC
) and capillary electrophoresis (
CE
) with detection at 214 nm. The lower limit of quantitative determination (15 ng/mL) was achieved with HPLC. The higher accuracy (
CV
), precision and selectivity have been achieved with CE method, 0.09, 90, and 100%, respectively. The sample preparation of blood plasma and previously homogenized prostate gland tissue included solid-phase extraction on Supelco DSC-18 cartridges. The recovery of vinblastine from the blood plasma was 91 ± 3% and from the tissue, 82 ± 5% (
n
= 6). The developed methods were implemented for the therapeutic monitoring of vinblastine in the procedure of intracavitary drug electrophoresis. |
| doi_str_mv | 10.1134/S1061934813030118 |
| format | article |
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HPLC
) and capillary electrophoresis (
CE
) with detection at 214 nm. The lower limit of quantitative determination (15 ng/mL) was achieved with HPLC. The higher accuracy (
CV
), precision and selectivity have been achieved with CE method, 0.09, 90, and 100%, respectively. The sample preparation of blood plasma and previously homogenized prostate gland tissue included solid-phase extraction on Supelco DSC-18 cartridges. The recovery of vinblastine from the blood plasma was 91 ± 3% and from the tissue, 82 ± 5% (
n
= 6). The developed methods were implemented for the therapeutic monitoring of vinblastine in the procedure of intracavitary drug electrophoresis.</description><identifier>ISSN: 1061-9348</identifier><identifier>EISSN: 1608-3199</identifier><identifier>DOI: 10.1134/S1061934813030118</identifier><language>eng</language><publisher>Dordrecht: SP MAIK Nauka/Interperiodica</publisher><subject>Analytical Chemistry ; Blood plasma ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Composition ; Electrophoresis ; High performance liquid chromatography ; Identification and classification ; Methods ; Pharmaceutical chemistry ; Physiological aspects ; Prostate ; Vinblastine</subject><ispartof>Journal of analytical chemistry (New York, N.Y.), 2013-03, Vol.68 (3), p.265-271</ispartof><rights>Pleiades Publishing, Ltd. 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-3f872703fb35f59696a487e33d10e35b0219c285e7968f1ceab9ff664a8c0bcd3</citedby><cites>FETCH-LOGICAL-c427t-3f872703fb35f59696a487e33d10e35b0219c285e7968f1ceab9ff664a8c0bcd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Sidorova, A. A.</creatorcontrib><creatorcontrib>Yaroshenko, D. V.</creatorcontrib><creatorcontrib>Murashko, E. A.</creatorcontrib><creatorcontrib>Grigor’ev, A. V.</creatorcontrib><title>Development of chromatographic and electrophoretic methods for determining vinblastine in blood plasma and prostate gland tissue</title><title>Journal of analytical chemistry (New York, N.Y.)</title><addtitle>J Anal Chem</addtitle><description>Two methods have been developed for determining antitumor drug vinblastine in blood plasma and prostate gland tissue by high performance liquid chromatography (
HPLC
) and capillary electrophoresis (
CE
) with detection at 214 nm. The lower limit of quantitative determination (15 ng/mL) was achieved with HPLC. The higher accuracy (
CV
), precision and selectivity have been achieved with CE method, 0.09, 90, and 100%, respectively. The sample preparation of blood plasma and previously homogenized prostate gland tissue included solid-phase extraction on Supelco DSC-18 cartridges. The recovery of vinblastine from the blood plasma was 91 ± 3% and from the tissue, 82 ± 5% (
n
= 6). The developed methods were implemented for the therapeutic monitoring of vinblastine in the procedure of intracavitary drug electrophoresis.</description><subject>Analytical Chemistry</subject><subject>Blood plasma</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Composition</subject><subject>Electrophoresis</subject><subject>High performance liquid chromatography</subject><subject>Identification and classification</subject><subject>Methods</subject><subject>Pharmaceutical chemistry</subject><subject>Physiological aspects</subject><subject>Prostate</subject><subject>Vinblastine</subject><issn>1061-9348</issn><issn>1608-3199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kU1LxDAQhoso-PkDvAU8eahmmm6bHMVvEAQ_ziVNJ91Im5QkK3rzp5t1vSwukkOSd55nDjNZdgz0DICV589AKxCs5MAoowB8K9uDivKcgRDb6Z3K-bK-m-2H8EYpFRyqvezrCt9xcNOINhKniZp7N8roei-nuVFE2o7ggCp6N82dx5iyEePcdYFo50mHEf1orLE9eTe2HWSIxiIxlrSDcx2ZUjLKnz6TdyHKiKQflt9oQljgYbaj5RDw6Pc-yF5vrl8u7_KHx9v7y4uHXJVFHXOmeV3UlOmWzfRMVKKSJa-RsQ4osllLCxCq4DOsRcU1KJSt0LqqSskVbVXHDrKTVd9eDtgYq130Uo0mqOaCMVaXBYMyUfkGqkeLXg7OojYpXuPPNvDpdDgatVE4XRMSE_Ej9nIRQnP__LTOwopVaXDBo24mb0bpPxugzXLrzZ-tJ6dYOSGxtkffvLmFt2my_0jfOtiu0Q</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Sidorova, A. A.</creator><creator>Yaroshenko, D. V.</creator><creator>Murashko, E. A.</creator><creator>Grigor’ev, A. V.</creator><general>SP MAIK Nauka/Interperiodica</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>20130301</creationdate><title>Development of chromatographic and electrophoretic methods for determining vinblastine in blood plasma and prostate gland tissue</title><author>Sidorova, A. A. ; Yaroshenko, D. V. ; Murashko, E. A. ; Grigor’ev, A. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-3f872703fb35f59696a487e33d10e35b0219c285e7968f1ceab9ff664a8c0bcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analytical Chemistry</topic><topic>Blood plasma</topic><topic>Chemical properties</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Composition</topic><topic>Electrophoresis</topic><topic>High performance liquid chromatography</topic><topic>Identification and classification</topic><topic>Methods</topic><topic>Pharmaceutical chemistry</topic><topic>Physiological aspects</topic><topic>Prostate</topic><topic>Vinblastine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sidorova, A. A.</creatorcontrib><creatorcontrib>Yaroshenko, D. V.</creatorcontrib><creatorcontrib>Murashko, E. A.</creatorcontrib><creatorcontrib>Grigor’ev, A. V.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sidorova, A. A.</au><au>Yaroshenko, D. V.</au><au>Murashko, E. A.</au><au>Grigor’ev, A. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of chromatographic and electrophoretic methods for determining vinblastine in blood plasma and prostate gland tissue</atitle><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle><stitle>J Anal Chem</stitle><date>2013-03-01</date><risdate>2013</risdate><volume>68</volume><issue>3</issue><spage>265</spage><epage>271</epage><pages>265-271</pages><issn>1061-9348</issn><eissn>1608-3199</eissn><abstract>Two methods have been developed for determining antitumor drug vinblastine in blood plasma and prostate gland tissue by high performance liquid chromatography (
HPLC
) and capillary electrophoresis (
CE
) with detection at 214 nm. The lower limit of quantitative determination (15 ng/mL) was achieved with HPLC. The higher accuracy (
CV
), precision and selectivity have been achieved with CE method, 0.09, 90, and 100%, respectively. The sample preparation of blood plasma and previously homogenized prostate gland tissue included solid-phase extraction on Supelco DSC-18 cartridges. The recovery of vinblastine from the blood plasma was 91 ± 3% and from the tissue, 82 ± 5% (
n
= 6). The developed methods were implemented for the therapeutic monitoring of vinblastine in the procedure of intracavitary drug electrophoresis.</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S1061934813030118</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-9348 |
| ispartof | Journal of analytical chemistry (New York, N.Y.), 2013-03, Vol.68 (3), p.265-271 |
| issn | 1061-9348 1608-3199 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A333742314 |
| source | Springer Link |
| subjects | Analytical Chemistry Blood plasma Chemical properties Chemistry Chemistry and Materials Science Composition Electrophoresis High performance liquid chromatography Identification and classification Methods Pharmaceutical chemistry Physiological aspects Prostate Vinblastine |
| title | Development of chromatographic and electrophoretic methods for determining vinblastine in blood plasma and prostate gland tissue |
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