Synthesis of 7-alkyl-4-amino-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acids

Two variants are discussed for the synthesis of ethyl N -alkyl- N -(6-amino-5-formylpyrimidin-4-yl)-glycinate derivatives, which are converted by intramolecular cyclization under the influence of sodium methoxide to give methyl 7 H -pyrrolo[2,3-d]pyrimidine-6-carboxylates. New derivatives of pyrimid...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-03, Vol.48 (12), p.1844-1852
Main Authors: Verves, E. V., Kucher, A. V., Muzychka, L. V., Smolii, O. B.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic acids
Organic Chemistry
Pharmacy
Pyrimidines
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Summary:Two variants are discussed for the synthesis of ethyl N -alkyl- N -(6-amino-5-formylpyrimidin-4-yl)-glycinate derivatives, which are converted by intramolecular cyclization under the influence of sodium methoxide to give methyl 7 H -pyrrolo[2,3-d]pyrimidine-6-carboxylates. New derivatives of pyrimido- [5',4':4,5]pyrrolo[2,1- c ][1,4]oxazines containing 3-chloropropyl groups at position 8 have been prepared.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-013-1218-0