Synthesis and pharmacological activity of amides of 2-amino-3-indolylacrylic acid

Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation to the various types of pharmacological activity typical of this class, including receptor...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2013, Vol.46 (10), p.584-590
Main Authors: Spasov, A. A., Yakovlev, D. S., Suzdalev, K. F., Kosolapov, V. A., Kucheryavenko, A. F., Gurova, N. A., Grechko, O. Yu, Naumenko, L. V., Kolobrodova, N. A., Mitina, T. M., Mal’tsev, D. V., Babakova, M. N.
Format: Article
Language:English
Subjects:
Amides
Anti-arrhythmia drugs
Antioxidants
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation to the various types of pharmacological activity typical of this class, including receptor (5-HT 2 -, 5-HT 3 -, and P2Y 1 -ergic, K-opioid), antiaggregant, hemorheological, antiarrhythmic, and antioxidant activities.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-013-0851-3