Apoptosis mediated by caspase-3 and p53-dependent anticancer effects of [sup.159]Gd-DTPA-BMA complex

In this work the apoptosis mediated by caspase-3 and p53-dependent anticancer effects of [sup.159]Gd-DTPA-BMA metal complex were evaluated against RT2 glioblastoma cells. The results showed that the mechanism of cell death involves apoptosis by caspase-3 activation. Furthermore, the involvement of p...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2013-01, Vol.295 (1), p.63
Main Authors: Soares, Daniel Cristian Ferreira, de Barros, Andre Luis Branco, dos Santos, Raquel Gouvea, de Sousa, Edesia Ma, Andrade Ramaldes, Gilson
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Cancer
Care and treatment
Health aspects
Rare earth metals
Ruthenium
Tumor proteins
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Summary:In this work the apoptosis mediated by caspase-3 and p53-dependent anticancer effects of [sup.159]Gd-DTPA-BMA metal complex were evaluated against RT2 glioblastoma cells. The results showed that the mechanism of cell death involves apoptosis by caspase-3 activation. Furthermore, the involvement of p53 protein triggered by [sup.159]Gd-DTPA-BMA in these cells was verified preliminarily. Considering these finding, the radioactive complex can be considered as potential therapeutic alternative agent against cancer. Keywords [sup.159]Gd-DTPA-BMA * Apoptosis * p53-Dependent anticancer effects
ISSN:0236-5731
DOI:10.1007/s10967-012-1870-3