FDG conjugated magnetic nanoparticle probes: synthesis and in vitro investigations on MCF-7 breast cancer cells

[sup.18]FDG conjugated magnetic iron oxide nanoparticles (MNPs) were synthesized as PET-MR hybrid imaging agent. Synthesized and characterized NPs were then applied to MCF-7 human breast cancer cells. [sup.18]FDG conjugated MNPs exhibited the cell incorporation ratio up to 30%. As well as the charac...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2013-03, Vol.295 (3), p.1789
Main Authors: Ozkaya, Feriha, Unak, Perihan, Medine, E. Ilker, Sakarya, Serhan, Unak, Gulcan, Timur, Suna
Format: Article
Language:English
Subjects:
Breast cancer
Cancer cells
Drug delivery systems
Drugs
Ferric oxide
Iron compounds
Magnetic properties
Magnetite
Medical imaging equipment
Monoclonal antibodies
Monosaccharides
Sugars
Vehicles
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Summary:[sup.18]FDG conjugated magnetic iron oxide nanoparticles (MNPs) were synthesized as PET-MR hybrid imaging agent. Synthesized and characterized NPs were then applied to MCF-7 human breast cancer cells. [sup.18]FDG conjugated MNPs exhibited the cell incorporation ratio up to 30%. As well as the characterization studies, apoptotic effects were observed depending on the cellular incorporations by the time. In conclusion, synthesized structures could have a potential as hybrid imaging agent in PET-MR imaging systems besides apoptotic effect on cancer cells. Keywords [sup.18]F * Magnetite nanoparticles * Mannose triflate * Apoptosis * Cancer diagnosis
ISSN:0236-5731
DOI:10.1007/s10967-012-2248-2