Long-term efficacy of an imidacloprid 10%/ flumethrin 4.5% polymer matrix collar in dogs

Two placebo-controlled pen studies were conducted to assess the efficacy of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®, Bayer; Investigational Veterinary Product (IVP)) against the Australian paralysis tick (Ixodes holocyclus). Dogs assigned to the placebo (n = 8) or IVP (n...

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Bibliographic Details
Published in:Parasitology research (1987) 2013-08, Vol.112, p.S1
Main Authors: Smith, Warwick M, Ahlstrom, Liisa A, Rees, Robert
Format: Article
Language:English
Subjects:
Control
Dogs
Dosage and administration
Drug therapy
Flea collars
Health aspects
Host-parasite relationships
Imidacloprid
Physiological aspects
Tick-borne diseases
Ticks
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Summary:Two placebo-controlled pen studies were conducted to assess the efficacy of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®, Bayer; Investigational Veterinary Product (IVP)) against the Australian paralysis tick (Ixodes holocyclus). Dogs assigned to the placebo (n = 8) or IVP (n > 8) groups had collars (placebo or IVP) attached on Day 0 and were infested with 30 unfed, adult, female I. holocyclus at 14-28 day intervals over 227 days. Ticks were counted 24, 48 and 72 h post infestation to determine the acaricidal efficacy of the IVP. The acaricidal efficacy of the IVP 72 h post infestation exceeded 95% on Days 17 (99.3%), 59 (99.7%), 73 (96.6%), 87 (100.0%), 101 (96.4%), 115 (99.1%) and 171 (95.8%), but dropped on Days 45 (94.0%) and 143 (77.8%), and declined from Day 199 (79.9%) to 227 (65.5%). No adverse events related to treatment were observed. This study has demonstrated the excellent acaricidal efficacy (97.9%) of the IVP collar against I. holocyclus 72 h post infestation over 16 weeks.
ISSN:0932-0113
DOI:10.1007/s00436-013-3276-8