Metabolic dysfunction and relationship in human frontoparietal cortex in severe traumatic brain injury: Single-voxel 1H magnetic resonance spectroscopy study

1 H-magnetic resonance spectroscopy revealed that apparently normal (from the data of magnetic resonance imaging) human brain frontoparietal cortex in the subacute stage of traumatic brain injury is characterized by decreased level of N-acetylaspartate (NAA) and increase in levels of myoinositol, ch...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2012-04, Vol.77 (4), p.388-394
Main Authors: Semenova, N. A., Akhadov, T. A., Petryaykin, A. V., Sidorin, S. S., Lukovenkov, A. V., Varfolomeev, S. D.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Brain
Injuries
Life Sciences
Metabolites
Microbiology
Nuclear magnetic resonance spectroscopy
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Summary:1 H-magnetic resonance spectroscopy revealed that apparently normal (from the data of magnetic resonance imaging) human brain frontoparietal cortex in the subacute stage of traumatic brain injury is characterized by decreased level of N-acetylaspartate (NAA) and increase in levels of myoinositol, choline-containing compounds (Cho), and creatine/phosphocreatine (Cr). Correlations between Cr, Cho, and NAA were established. We propose a scheme of neuronal metabolic processes that joins these substances.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297912040104