A microfluidic chip analyzer for determining neurotransmitters

The fabrication of a chip analyzer based on polydimethylsiloxane and glass has been described. The possibilities of the treatment of the chip channel surface by atmospheric plasma and sodium dodecyl sulphate used as an additive to the working buffer solution has been studied. The rate of electroosmo...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2013-12, Vol.68 (12), p.1093-1098
Main Authors: Nikolaev, A. V., Kartsova, L. A., Filimonov, V. V., Sukhanov, V. L.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Catecholamines
Chemistry
Chemistry and Materials Science
Electrophoresis
Health aspects
Microfluidics
Neurotransmitters
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Summary:The fabrication of a chip analyzer based on polydimethylsiloxane and glass has been described. The possibilities of the treatment of the chip channel surface by atmospheric plasma and sodium dodecyl sulphate used as an additive to the working buffer solution has been studied. The rate of electroosmotic flow was evaluated. Using a model mixture of catecholamines, the effect of modification of the surface of microchip channels on efficiency and separation factor was revealed. Methods for enhancing the sensitivity of the electrochemical cell have been developed; the possibilities of online preconcentration in the chip format were evaluated. The limit of detection for catecholamines has been attained at 10 −6 –10 −7 g/mL.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934813120083