Study of high-resolution [H.sup.1] nuclear magnetic resonance spectra of the serum and its albumin fraction in patients with the first schizophrenia episode

We studied high-resolution ¹H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the first episode of schizophrenia and healthy individuals. A relative increase in signal intensities of C[H.sub.2] protons in serum LDL and VLDL in schizophrenia was demonstrated. High...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-04, Vol.152 (6), p.748
Main Authors: Babushkina, T.A, Klimova, T.P, Peregudov, A.S, Gryzunov, Yu. A, Smolina, N.V, Dobretsov, G.E, Uzbekov, M.G
Format: Article
Language:English
Subjects:
Albumin
Blood lipids
Care and treatment
Cholesterol
Fatty acids
Low density lipoproteins
Nuclear magnetic resonance spectroscopy
Schizophrenia
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied high-resolution ¹H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the first episode of schizophrenia and healthy individuals. A relative increase in signal intensities of C[H.sub.2] protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of C[H.sub.2] and C[H.sub.3] protons of non-esterified fatty acids were found in ¹H nuclear magnetic resonance spectra of serum albumin. These data attest to an essential role of changes in lipid metabolism and changed ligand load of albumin in schizophrenia. Key Words: ¹H nuclear magnetic resonance spectroscopy; serum; lipids; albumin; first episode of schizophrenia
ISSN:0007-4888