Synthesis and antimicrobial activity of new phenytoin derivatives and their acyclic nucleoside analogs

New phenytoin derivatives and their N-substituted acyclic nucleoside analogs were prepared. The synthesized compounds were tested for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Streptomyces Sp. Most of the tested compounds exhibited moderate to high antimicrobi...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2012-10, Vol.48 (7), p.1043-1049
Main Authors: Ali, O. M., Amer, H. H., Mosaad, A. A., Abdel-Rahman, A. A.-H.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Dextrose
Glucose
Glucose metabolism
Nucleoside analogs
Organic Chemistry
Pharmacy
Phenytoin
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Summary:New phenytoin derivatives and their N-substituted acyclic nucleoside analogs were prepared. The synthesized compounds were tested for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Streptomyces Sp. Most of the tested compounds exhibited moderate to high antimicrobial activity while a few compounds were found to exhibit little or no activity against the tested microorganisms.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-012-1097-9