Radical scavenging activity of decalpoline, a novel compound characterized from Decalepis hamiltonii

The ethanol extract of Decalepis hamiltonii roots was subjected to antioxidant activity-guided fractionation by repeated silica gel column chromatography to get a pure antioxidant compound which was subjected to extensive analysis by UV, IR, LC-MS, and 2D HMQC NMR. The spectral data of the isolated...

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Bibliographic Details
Published in:Chemistry of natural compounds 2012-05, Vol.48 (2), p.225-230
Main Authors: Naveen, S., Policegoudra, R. S., Aradhya, S. M., Rao, L. J., Farhath, K.
Format: Article
Language:English
Subjects:
Antioxidants
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
Superoxide
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Summary:The ethanol extract of Decalepis hamiltonii roots was subjected to antioxidant activity-guided fractionation by repeated silica gel column chromatography to get a pure antioxidant compound which was subjected to extensive analysis by UV, IR, LC-MS, and 2D HMQC NMR. The spectral data of the isolated compound was analyzed, and its structure was elucidated as decalpoline, a novel antioxidant compound not reported so far. Decalpoline exhibited multiple antioxidant properties like DPPH scavenging activity, superoxide radical scavenging activity, lipid peroxidation inhibitory activity, metal chelating and total reducing activity.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-012-0210-8