Crystal structures of atisine 15-acetoxyazomethine and 15-hydroxyazomethine and their biological activities

The 15-acetoxyazomethine derivative of atisine was prepared from atisine base. Its structure was confirmed by converting it to atisine 15-hydroxyazomethine and proved by an XSA. Atisine 15-acetoxyazomethine exhibited antiarrhythmic activity in rat cardiac arrhythmia models induced by CaCl 2 and acon...

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Bibliographic Details
Published in:Chemistry of natural compounds 2011-05, Vol.47 (2), p.261-264
Main Authors: Salimov, B. T., Tashkhodzhaev, B., Kodirova, M. Sh, Tursunkhodzhaeva, F. M., Dzhakhangirov, F. N.
Format: Article
Language:English
Subjects:
Anti-arrhythmia drugs
Arrhythmia
Crystals
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
Structure
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Summary:The 15-acetoxyazomethine derivative of atisine was prepared from atisine base. Its structure was confirmed by converting it to atisine 15-hydroxyazomethine and proved by an XSA. Atisine 15-acetoxyazomethine exhibited antiarrhythmic activity in rat cardiac arrhythmia models induced by CaCl 2 and aconitine. Atisine 15-acetoxyazomethine, in contrast with atisine 15-hydroxyazomethine, exhibited local anesthetic activity.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-011-9897-1