Synthesis and Psychotropic Activity of Arylhydroxyphosphorylacetic Acid Hydrazides and their Salts

A number of the pharmacological effects of new phosphorylacetohydrazides with different types of cationic fragments were studied. These compounds had anxiolytic activity, along with positive influences on memory and learning. The relationship between the activities of these compounds and their chemi...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2013-11, Vol.47 (8), p.415-418
Main Authors: Pashina, I. P., Semina, I. I., Sidullina, S. A., Tarasova, R. I., Gazizov, M. B., Mustafin, R. I.
Format: Article
Language:English
Subjects:
Activity programs in education
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Quality control
Search for New Drugs
Tranquilizing drugs
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Summary:A number of the pharmacological effects of new phosphorylacetohydrazides with different types of cationic fragments were studied. These compounds had anxiolytic activity, along with positive influences on memory and learning. The relationship between the activities of these compounds and their chemical structures was studied. Adetailed pharmacological analysis of one of the most active compounds – compound IX, which had marked mnemotropic actions and low toxicity – is presented. This compound is the norephedrine salt of 4-fluorophenylhydroxyphosphorylacetic acid hydrazide. The structure of this compound was confirmed by elemental analysis and IR and UV spectroscopy. Pharmaceutical analysis included development of an identification method, quality monitoring, and assay.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-013-0971-9