Vitamin A and vitamin E interaction behavior on chitosan microspheres: A calorimetric view

• Published in: Journal of thermal analysis and calorimetry 2011-11, Vol.106 (2), p.415-420
• Main Authors: Prado, Alexandre G. S., Santos, André L. F., Pedroso, Carolina P., Carvalho, Thiago O., Braga, Lilian R., Evangelista, Sheila M.
• Format: Article
• Language: English
• Subjects: Adsorption; Analytical Chemistry; Applied sciences; Calorimetry; Chemical industry and chemicals; Chemistry; Chemistry and Materials Science; Cosmetics, toiletries; Exact sciences and technology; Inorganic Chemistry; Measurement Science and Instrumentation; Physical Chemistry; Polymer Sciences; Thermodynamics; Vitamin A; Vitamin E; Washing products. Cosmetics and toiletries. Perfumes
• ISSN: 1388-6150; 1588-2926; 1572-8943
• DOI: 10.1007/s10973-011-1418-8

Chitosan is a biodegradable natural polymer with great potential for pharmaceutical applications due to its biocompatibility, high charge density, and non-toxicity. In this study, chitosan microspheres were successfully prepared by an adapted method of coagulation/dispersion. The degree of deacetylation of chitosan powder was obtained by NMR 1 H and FTIR techniques. Chitosan powder and chitosan microspheres were characterized by BET surface area and scanning electron microscopy (SEM) . The interactions among the chitosan microspheres and the vitamins A and E were characterized by FTIR. In order to evaluate the ability of interaction of vitamin A and vitamin E with the chitosan microspheres, the thermodynamic parameters were followed by calorimetric titration. Different experimental approaches were applied, such as adsorption isotherms, kinetics and thermodynamics studies. The obtained results showed that the interactions of chitosan microspheres with the vitamins were spontaneous, enthalpically and entropically favorable, indicating that the chitosan microspheres can be used with success in the controlled release of these vitamins.