Synthesis and antifungal activity of 3-hydroxy-7,7-dialkyl-7,8-dihydroindolo[2,1-a]isoquinolinecarboxylic acid amides

Reaction of enaminoamides of the 1,2,3,4-tetrahydroisoquinoline series with p-benzoquinone yielded 3-hydroxy-7,7-dialkyl-7,8-dihydroindolo[2,1-a]-isoquinolinecarboxylic acid amides. Use of benzo[f]isoquinoline as the enamine resulted in synthesis of the relatively unknown benzo[f]indolo[2,1-a]isoqui...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal 2010-10, Vol.44 (6), p.296-298
Main Authors: Surikova, O. V, Mikhailovskii, A. G, Pershina, N. N, Aleksandrova, G. A, Semeriko, V. V, Vakhrin, M. I
Format: Article
Language:English
Subjects:
3-hydroxy-7,7-dialkyl-7,8-dihydroindolo[2,1-a]-isoquinolinecarboxylic acid amides
Amides
antifungal activity
Antifungal agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Quinone
Search for New Drugs
synthesis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reaction of enaminoamides of the 1,2,3,4-tetrahydroisoquinoline series with p-benzoquinone yielded 3-hydroxy-7,7-dialkyl-7,8-dihydroindolo[2,1-a]-isoquinolinecarboxylic acid amides. Use of benzo[f]isoquinoline as the enamine resulted in synthesis of the relatively unknown benzo[f]indolo[2,1-a]isoquinoline system. The fungicidal activity of the compounds synthesized here was studied and the most active was the hexamethyleneimide, which was active at a concentration of 500 μg/ml.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0453-2