Effect of cellulose sulfate on the induction of hydrolysis of plasmin-specific chromogenic substrate and anticoagulant activity in rabbit blood plasma

Rabbit plasma coagulation time in the APTT and ReaClot-heparin tests, antithrombin and anti-factor Xa activities of plasma, and the effective half-life and duration of action increase with dose (0.3 to 10 mg/kg, i.v.) of injected cellulose sulfate (molecular weight 10 – 30 kDa, degree of sulfonation...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2012-05, Vol.46 (2), p.86-91
Main Authors: Savchik, E. Yu, Kalinina, T. B., Gurvits, I. D., Torlopov, M. A., Drozd, N. N., Makarov, V. A., Kuchin, A. V.
Format: Article
Language:English
Subjects:
Anticoagulants (Medicine)
Cellulose
Glycosaminoglycans
Hydrolysis
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Sulfates
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Summary:Rabbit plasma coagulation time in the APTT and ReaClot-heparin tests, antithrombin and anti-factor Xa activities of plasma, and the effective half-life and duration of action increase with dose (0.3 to 10 mg/kg, i.v.) of injected cellulose sulfate (molecular weight 10 – 30 kDa, degree of sulfonation 1.8, antithrombin activity 130 ± 12 IU/mg, anti-factor Xa activity 45 ± 3.3 IU/mg). Cellulose sulfate independently neither influences human platelet aggregation nor potentiates adenosinediphosphate-induced human platelet aggregation and fibrinolytic activity of plasma euglobulin fraction in vivo but it favors an increase in the fibrinolytic activity of plasma upon intravenous injection in rabbits.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-012-0739-7