Synthesis and analgesic activity of N',N'-dialkylhydradizes of aliphatic carboxylic acids

A series of new N',N'-dialkylhydrazides of aliphatic carboxylic acids have been obtained. It is shown that some of these compounds possess central analgesic activity and exhibit low toxicity. N',N'-dialkylhydrazides of octanoic acid are of interest for further investigation in th...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2010-08, Vol.44 (4), p.192-194
Main Authors: Batueva, T. D, Anikina, L. V, Gusev, V. Yu, Maiorova, O. A, Radushev, A. V
Format: Article
Language:English
Subjects:
analgesic effect
Analgesics
Medicine
N',N'-dialkylhydrazides of aliphatic carboxylic acids
Organic acids
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
synthesis
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Summary:A series of new N',N'-dialkylhydrazides of aliphatic carboxylic acids have been obtained. It is shown that some of these compounds possess central analgesic activity and exhibit low toxicity. N',N'-dialkylhydrazides of octanoic acid are of interest for further investigation in the search for new neurotropic agents.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0429-2