Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS

This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. T...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2011-12, Vol.106 (3), p.763-766
Main Authors: de Oliveira, Agna Hélia, de Moura, Elisana Afonso, Pinto, Márcia Ferraz, Procópio, José Valdilânio Virgulino, de Souza, Valmir Gomes, de Souza, Fábio Santos, Macêdo, Rui Oliveira
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biological and medical sciences
Cardiovascular system
Chemical properties
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Mass spectrometry
Measurement Science and Instrumentation
Medical sciences
Methods
Pentoxifylline
Pharmacology. Drug treatments
Physical Chemistry
Polymer Sciences
Pyrolysis
Raw materials
Vasodilator agents. Cerebral vasodilators
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Summary:This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline.
ISSN:1388-6150
1588-2926
1572-8943
DOI:10.1007/s10973-011-1839-4