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Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS

This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. T...

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Published in:	Journal of thermal analysis and calorimetry 2011-12, Vol.106 (3), p.763-766
Main Authors:	de Oliveira, Agna Hélia, de Moura, Elisana Afonso, Pinto, Márcia Ferraz, Procópio, José Valdilânio Virgulino, de Souza, Valmir Gomes, de Souza, Fábio Santos, Macêdo, Rui Oliveira
Format:	Article
Language:	English
Subjects:	Analytical Chemistry Biological and medical sciences Cardiovascular system Chemical properties Chemistry Chemistry and Materials Science Inorganic Chemistry Mass spectrometry Measurement Science and Instrumentation Medical sciences Methods Pentoxifylline Pharmacology. Drug treatments Physical Chemistry Polymer Sciences Pyrolysis Raw materials Vasodilator agents. Cerebral vasodilators
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container_title	Journal of thermal analysis and calorimetry
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creator	de Oliveira, Agna Hélia de Moura, Elisana Afonso Pinto, Márcia Ferraz Procópio, José Valdilânio Virgulino de Souza, Valmir Gomes de Souza, Fábio Santos Macêdo, Rui Oliveira
description	This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline.
doi_str_mv	10.1007/s10973-011-1839-4
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The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline.</description><subject>Analytical Chemistry</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Inorganic Chemistry</subject><subject>Mass spectrometry</subject><subject>Measurement Science and Instrumentation</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Pentoxifylline</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Pyrolysis</topic><topic>Raw materials</topic><topic>Vasodilator agents. 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The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10973-011-1839-4</doi><tpages>4</tpages></addata></record>
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subjects	Analytical Chemistry Biological and medical sciences Cardiovascular system Chemical properties Chemistry Chemistry and Materials Science Inorganic Chemistry Mass spectrometry Measurement Science and Instrumentation Medical sciences Methods Pentoxifylline Pharmacology. Drug treatments Physical Chemistry Polymer Sciences Pyrolysis Raw materials Vasodilator agents. Cerebral vasodilators
title	Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS
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