The antioxidant and membrane-stabilizing properties of 1--3-aminopropan-1-ol hydrochlorides in vitro

In vitro model systems were used to study the antioxidant and membrane- stabilizing properties of 1-(4-substituted phenyl)-2H-(phenyl)-3-aminopropan-1-ol hydrochlorides. These secondary aminopropanols, whose synthesis is first reported here, were found not to have any significant antioxidant or anti...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-02, Vol.44 (11), p.591
Main Authors: Malakyan, M.G, Badzhinyan, S.A, Vardevanyan, L.A, Papoyan, O.A, Isakhanyan, A.U, Gevorgyan, G.A
Format: Article
Language:English
Subjects:
Antioxidants
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Summary:In vitro model systems were used to study the antioxidant and membrane- stabilizing properties of 1-(4-substituted phenyl)-2H-(phenyl)-3-aminopropan-1-ol hydrochlorides. These secondary aminopropanols, whose synthesis is first reported here, were found not to have any significant antioxidant or antiradical activity either in an ascorbate-dependent Fe(II)-stimulated peroxidation system, in a method based on the spectrophotometric monitoring of decreases in the concentration of the stable radical 1,1-diphenyl- 2-picrylhydrazyl, or in the photochemiluminescence analysis method. However these compounds had marked antihemolytic effects in an erythrocyte oxidative stress model. It is suggested that the new 1-(4- substituted phenyl)-2H-(phenyl)-3-aminopropan- 1-ol hydrochlorides are biologically active compounds with weak antioxidant properties, capable of membrane-stabilizing actions due to interaction with the structural components of cell membranes. Key words: Aminopropan-1-ols, antioxidant activity, membrane-stabilizing properties, erythrocytes, hemolysis.
ISSN:0091-150X