Comparative analysis of the experimental and clinical pharmacokinetics of Amiodarone

The pharmacokinetics of two tablet formulations of amiodarone – Amiodarone and Amiodaron-Akri – were studied in 12 rabbits and 18 healthy human volunteers after single p.o. doses of 200 mg. A highly statistically significant correlation was found between plasma amiodarone concentrations in rabbits a...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-07, Vol.45 (4), p.199, Article 199
Main Authors: Kukes, V. G., Kondratenko, S. N., Starodubtsev, A. K., Chistyakov, V. V., Posrednikova, T. A.
Format: Article
Language:English
Subjects:
Amiodarone
Medicine
Molecular-Biological Problems of Drug Design and Mechanisms of Drug Action
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:The pharmacokinetics of two tablet formulations of amiodarone – Amiodarone and Amiodaron-Akri – were studied in 12 rabbits and 18 healthy human volunteers after single p.o. doses of 200 mg. A highly statistically significant correlation was found between plasma amiodarone concentrations in rabbits and volunteers ( r  = 0.8263, p  
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0592-0