Synthesis and biological properties of 1--2-phenyl-3-piperidinopropan-1-ols

Interaction of [alpha]-phenyl-[beta]-piperidino-4-substituted propiophenones with Grignard reagents in ether was used to synthesize 1-(4-substitutedphenyl)-1-alkyl(aryl)-2-phenyl-3-piperidinopropan-1-ols. The antibacterial and antioxidant properties of the aminopropanol hydrochlorides were studied....

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-07, Vol.45 (4), p.224
Main Authors: Gasparyan, N.K, Vardevanyan, L.A, Egiazaryan, D.E, Malakyan, M.N, Badzhinyan, S.A, Avakimyan, D.A, Panosyan, G.A, Gevorgyan, G.A
Format: Article
Language:English
Subjects:
Antioxidants
Chemical tests and reagents
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Summary:Interaction of [alpha]-phenyl-[beta]-piperidino-4-substituted propiophenones with Grignard reagents in ether was used to synthesize 1-(4-substitutedphenyl)-1-alkyl(aryl)-2-phenyl-3-piperidinopropan-1-ols. The antibacterial and antioxidant properties of the aminopropanol hydrochlorides were studied. Some of these compounds (3-(4-ethoxyphenyl)-2-phenyl-1-piperidinoheptan-, 3-(4-ethoxyphenyl)-2-phenyl-1-piperidonooctan-, and 2-phenyl-1-piperidino-3-(4-propoxyphenyl)decan-3-ol hydrochlorides) had moderate antibacterial activity and some (3-(4-ethoxyphenyl)-2-phenyl-1-piperidinopentan- and 3-(4-ethoxyphenyl)-5-methyl-2-phenyl-1-piperidinohexan-3-ol hydrochlorides) had high antioxidant activity. Key words: Aminomethylation, [beta]-piperidinopropiophenones, piperidinopropan-1-ols, antibacterial and antioxidant activity.
ISSN:0091-150X