Determination of desmopressin by HPLC–MS

Desmopressin is used for preventing and stopping hemorrhage of various etiologies and is included in the list of most essential drugs. Quantative determination of desmopressin in blood plasma using gas chromatography—mass spectrometry (HPLC/MS) is discussed. A method for the isolation of desmopressi...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-11, Vol.45 (8), p.509-511
Main Authors: Nguyen, C. T., Karlitskaya, A. A., Davydova, K. S., Kukes, V. G.
Format: Article
Language:English
Subjects:
Chromatography
Desmopressin
Desmopressin acetate
Hemophilia
Ionization
Medicine
Methods of Analysis and Process Control
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Structure of Chemical Compounds
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Summary:Desmopressin is used for preventing and stopping hemorrhage of various etiologies and is included in the list of most essential drugs. Quantative determination of desmopressin in blood plasma using gas chromatography—mass spectrometry (HPLC/MS) is discussed. A method for the isolation of desmopressin from plasma samples and quantitative determination of desmopressin is described. The percent extraction of the drug from blood plasma has been estimated and the influence of the biological matrix has been assessed. The work has been carried out using a Thermo Finnigan HPLC/MS instrument equipped with an external ion-source based on electrospray ionization.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0666-z