Adaptogenic properties of polyprenols isolated from fir greenery in a rat-immobilization stress model

The adaptogenic effect of polyprenols isolated from fir greenery was studied. It was established that a single oral administration of polyprenols at a dose of 0.25 mL/100 g in male rats (140 – 150 g) under conditions of immobilization stress prevented significantly involution of the thymic-lymphatic...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2012-10, Vol.46 (7), p.438-440
Main Authors: Syrov, V. N., Hurshkainen, T. V., Tsaruk, A. V., Egamova, F. R., Khushbaktova, Z. A., Kuchin, A. V.
Format: Article
Language:English
Subjects:
Medicine
Organic acids
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:The adaptogenic effect of polyprenols isolated from fir greenery was studied. It was established that a single oral administration of polyprenols at a dose of 0.25 mL/100 g in male rats (140 – 150 g) under conditions of immobilization stress prevented significantly involution of the thymic-lymphatic system and hypertrophy of the adrenal glands and reduced the content of ascorbic acid and cholesterol. In addition, there was a decrease in the level of stress-activated lipid peroxidation processes and normalization of the functioning of antioxidant and NO-ergic systems of liver hepatocytes.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-012-0816-y