Tc-meropenem as a potential SPECT imaging probe for tumor hypoxia

Meropenem was successfully radiolabeled with [sup.99m]Tc in high labeling yield (92 [+ or -] 2%) and stability (~6 h). [sup.99m]Tc-meropenem showed high accumulation in tumor hypoxic tissue (4.193% injected dose/g organ). [sup.99m]Tc-meropenem showed high ability to differentiate the tumor tissue fr...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2012-05, Vol.292 (2), p.705
Main Authors: Sakr, T.M, Motaleb, M.A, Ibrahim, I.T
Format: Article
Language:English
Subjects:
Beta lactam antibiotics
Investigations
PET imaging
SPECT imaging
Tumors
Online Access:Get full text
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Summary:Meropenem was successfully radiolabeled with [sup.99m]Tc in high labeling yield (92 [+ or -] 2%) and stability (~6 h). [sup.99m]Tc-meropenem showed high accumulation in tumor hypoxic tissue (4.193% injected dose/g organ). [sup.99m]Tc-meropenem showed high ability to differentiate the tumor tissue from inflamed or infected tissues in different mice models as its T/NT ratio ~4 in case of tumor mice model while T/NT ratio ~1 in case of inflamed mice model. So, [sup.99m]Tc-meropenem showed high selectivity in comparison with FDG-PET and [sup.99m]Tc-nitroimidazole analogues. Thus, [sup.99m]Tc-meropenem could be used as a selective potential imaging agent for diagnosis of tumor hypoxia. Keywords Meropenem * [sup.99m]Tc * SPECT * Tumor * Imaging * Hypoxia
ISSN:0236-5731
DOI:10.1007/s10967-011-1481-4