Sjogren syndrome or Sjogrena disease? The histological and immunological bias caused by the 2002 criteria

The current 2002 classification criteria do not cover the broad clinical and immunological heterogeneity of primary Sjogren syndrome (SS), since five of the six criteria focus exclusively on glandular involvement and the remaining criterion is the mandatory presence of anti-Ro/La antibodies. The aim...

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Bibliographic Details
Published in:Clinical reviews in allergy & immunology 2010-04, Vol.38 (2-3), p.178
Main Authors: Ramos-Casals, Manuel, Brito-Zeron, Pilar, Perez-De-Lis, Marta, Jimenez, Iratxe, Blanco, Maria-Jose, Bove, Albert, Soto, Maria-Jose, Akasbi, Miriam, Diaz, Candido, Sentis, Juan, Siso, Antoni
Format: Article
Language:English
Subjects:
Analysis
Autoimmunity
Health aspects
Rheumatoid factor
Systemic lupus erythematosus
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Summary:The current 2002 classification criteria do not cover the broad clinical and immunological heterogeneity of primary Sjogren syndrome (SS), since five of the six criteria focus exclusively on glandular involvement and the remaining criterion is the mandatory presence of anti-Ro/La antibodies. The aim of this study was to analyze the clinical features of patients with a well-established diagnosis of primary SS who do not fulfill the 2002 classification criteria. Five hundred seven patients diagnosed with primary SS (1993 criteria) were consecutively included and followed up. Two hundred twenty-one (44%) patients did not fulfill the 2002 criteria. These patients were older at diagnosis (p
ISSN:1080-0549
DOI:10.1007/s12016-009-8152-z