Designing gene therapy vectors targeting tumor cell endothelium/Kanserde damar endoteline yonelik gen tedavisi ajanlari gelistirilmesi

Anjiyogenez tumor hucrelerinin buyuyup gelismesi icin de zorunlu bir surectir. Bu surecin cok fazla sayida molekul, protein ve yolak iceriyor olmasi onu gen tedavisinin hedeflerinden biri haline getirmistir. Anti-anjiyogenik gen tedavisinde, kanser damar endoteline yonelik ajanlar gelistirmek yeni s...

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Bibliographic Details
Published in:Türk onkoloji dergisi 2013-12, Vol.28 (4), p.179
Main Authors: Ozkal Baydin, Pinar, Akbulut, Hakan
Format: Article
Language:Turkish
Online Access:Get full text
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Summary:Anjiyogenez tumor hucrelerinin buyuyup gelismesi icin de zorunlu bir surectir. Bu surecin cok fazla sayida molekul, protein ve yolak iceriyor olmasi onu gen tedavisinin hedeflerinden biri haline getirmistir. Anti-anjiyogenik gen tedavisinde, kanser damar endoteline yonelik ajanlar gelistirmek yeni stratejiler arasindadir. Anahtar sozcukler: Gen tedavisi; interseluler adezyon molekulu2; kanser; sitozin deaminaz vaskuler endotel. Angiogenesis is essential for tumor growth and metastasis. Targeting angiogenesis is one of the recent progresses in the therapeutic area of cancer. Gene therapy is one of the promising strategies in the treatment of cancer. The gene therapy vectors targeting tumor endothelium carry the great therapeutic potential in cancer. Key words: Gene therapy; intercellular adhesion molecule2; cancer; cytosine deaminase vascular endothel.
ISSN:1300-7467
DOI:10.5505/tjoncol.2013.947