Involvement of [P2Y.sub.2, 4] receptors in the regulation of myocardial contractility in growing rats

Experiments with R2Y receptor blockers allowed identification of R2Y subtypes mediating the inhibitory effects of uridine triphosphate on myocardial contractility. In 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by [R2Y.sub.2] rece...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-01, Vol.156 (3), p.299
Main Authors: Anikina, T.A, Anisimova, I.N, Zverev, A.A, Sitdikov, F.G, Zefirov, T.L
Format: Article
Language:English
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Summary:Experiments with R2Y receptor blockers allowed identification of R2Y subtypes mediating the inhibitory effects of uridine triphosphate on myocardial contractility. In 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by [R2Y.sub.2] receptors. [R2Y.sub.4] receptors took part in the realization of negative inotropic response to uridine triphosphate in all age groups, but the most pronounced effects of this substance on myocardial contractility were found in 100-day-old rats. It was found that R2Y receptor blockers PPADS and reagent blue-2 affect amplitude-time parameters of myocardial contractility in rats of various ages. Key Words: purine receptors; heart; ontogeny, myocardial contractility
ISSN:0007-4888