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Contributions of specific and nonspecific interactions in the complexation of esters of 7-bromo-3-hydroxy-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with central benzodiazepine receptors

Radioligand analysis at 0-35 °C was used to find that 3-(alkylcarbonyloxy)-7-bromo-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones react differently with central benzodiazepine receptors. The complexation of the 3-acetyloxy derivative proceeds endothermally with Δ S 0 as the driving force...

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Published in:Theoretical and experimental chemistry 2012-11, Vol.48 (5), p.320-326
Main Authors: Andronati, S. A., Smulsky, S. P., Pavlovsky, V. I., Boyko, I. A., Yurpalova, T. A., Polishchuk, P. G.
Format: Article
Language:English
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Summary:Radioligand analysis at 0-35 °C was used to find that 3-(alkylcarbonyloxy)-7-bromo-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones react differently with central benzodiazepine receptors. The complexation of the 3-acetyloxy derivative proceeds endothermally with Δ S 0 as the driving force. The reaction of the other esters is accompanied by favorable change of both entropy and enthalpy.
ISSN:0040-5760
1573-935X
DOI:10.1007/s11237-012-9276-4