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Contributions of specific and nonspecific interactions in the complexation of esters of 7-bromo-3-hydroxy-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with central benzodiazepine receptors
Radioligand analysis at 0-35 °C was used to find that 3-(alkylcarbonyloxy)-7-bromo-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones react differently with central benzodiazepine receptors. The complexation of the 3-acetyloxy derivative proceeds endothermally with Δ S 0 as the driving force...
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Published in: | Theoretical and experimental chemistry 2012-11, Vol.48 (5), p.320-326 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Radioligand analysis at 0-35 °C was used to find that 3-(alkylcarbonyloxy)-7-bromo-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones react differently with central benzodiazepine receptors. The complexation of the 3-acetyloxy derivative proceeds endothermally with Δ
S
0
as the driving force. The reaction of the other esters is accompanied by favorable change of both entropy and enthalpy. |
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ISSN: | 0040-5760 1573-935X |
DOI: | 10.1007/s11237-012-9276-4 |