Synthesis and anxiolytic activity of 2-aminoadamantane derivatives containing monoterpene fragments

Two new amines were synthesized from 2-aminoadamantane and the available monoterpenoid aldehydes citral and (–)-myrtenal. It was established that the synthesized amines possessed anxiolytic activity.

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2012-08, Vol.46 (5), p.263-265
Main Authors: Kapitsa, I. G., Suslov, E. V., Teplov, G. V., Korchagina, D. V., Komarova, N. I., Volcho, K. P., Voronina, T. A., Shevela, A. I., Salakhutdinov, N. F.
Format: Article
Language:English
Subjects:
Amantadine
Amines
Antianxiety agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Description
Summary:Two new amines were synthesized from 2-aminoadamantane and the available monoterpenoid aldehydes citral and (–)-myrtenal. It was established that the synthesized amines possessed anxiolytic activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-012-0775-3