Investigation of the stability and efficacy of iodine-containing drugs in solid dosage forms

The stability and efficacy of iodine-containing caramels were investigated. In the case of a caramel containing potassium iodide, iodine losses during three months of storage at 60 °C did not exceed 7.9 %. Preclinical trials showed that use of this caramel increased the urinary iodine level to a gre...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2012-08, Vol.46 (5), p.303-305
Main Authors: Sablina, O. S., Levchuk, L. V., Tumashov, A. A., Gavrilov, A. S.
Format: Article
Language:English
Subjects:
Elementary school students
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Potassium iodide
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Summary:The stability and efficacy of iodine-containing caramels were investigated. In the case of a caramel containing potassium iodide, iodine losses during three months of storage at 60 °C did not exceed 7.9 %. Preclinical trials showed that use of this caramel increased the urinary iodine level to a greater extent than did reference iodine-containing tablets. Clinical trials with caramel showed a statistically significant increase in the median urinary iodine level up to 126.1 μg/L in primary school children against an initial level of 97.1 μg/L ( p  
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-012-0785-1