Effect of in vivo irradiation of blood by therapeutic doses of optical radiation on metabolic processes

We have studied the effect of in vivo irradiation of venous blood by therapeutic doses of optical radiation at different wavelengths (254 nm and 670 nm) on the absorption spectra of blood, the level of hemoglobin oxygen saturation in erythrocytes, and also the blood lactate and glucose levels for in...

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Bibliographic Details
Published in:Journal of applied spectroscopy 2013-03, Vol.80 (1), p.111-116
Main Authors: Zalesskaya, G. A., Laskina, O. V.
Format: Article
Language:English
Subjects:
Active oxygen
Analytical Chemistry
Atomic/Molecular Structure and Spectra
Bioremediation
Dextrose
Glucose
Glucose metabolism
Health aspects
Hemoglobin
Lactates
Metabolites
Physics
Physics and Astronomy
Radiation
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Summary:We have studied the effect of in vivo irradiation of venous blood by therapeutic doses of optical radiation at different wavelengths (254 nm and 670 nm) on the absorption spectra of blood, the level of hemoglobin oxygen saturation in erythrocytes, and also the blood lactate and glucose levels for individual patients before and after irradiation of the blood. We have determined the differences in short-term (achieved during irradiation) and long-term photoinduced changes in metabolite levels. The changes in the lactate and glucose concentrations measured after completion of the course of treatment were appreciably different for different patients, and depended on two quantities: their initial concentration, and the photoinduced changes in the oxygen saturation of venous blood (Δ S v O 2 ). The strongest normalizing effect of optical radiation occurred for changes in Δ S v O 2 in the narrow range −15% < Δ S v O 2 < 10%.
ISSN:0021-9037
1573-8647
DOI:10.1007/s10812-013-9729-0