Free and protein-bound angiotensin [II.sub.1-7] in the regulation of drinking behavior and hemodynamics in rats

We compared physiological activity of synthetic analogues of endogenous protein-peptide compounds, complexes of angiotensin [II.sub.1-7] with functionally different proteins (transport protein, serum albumin; and neurospecific [Ca.sup.2+]-binding protein, S100b). Physiological activity of angiotensi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-09, Vol.153 (5), p.623
Main Authors: Tolpygo, S.M, Pevtsova, E.I, Shoibonov, B.B, Kotov, A.V
Format: Article
Language:English
Subjects:
Angiotensin
Physiological aspects
Protein binding
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Summary:We compared physiological activity of synthetic analogues of endogenous protein-peptide compounds, complexes of angiotensin [II.sub.1-7] with functionally different proteins (transport protein, serum albumin; and neurospecific [Ca.sup.2+]-binding protein, S100b). Physiological activity of angiotensin [II.sub.1-7] was shown to depend on the type of a carrier protein. Our results suggest that complexes of angiotensins with BSA and S100b are strong factors for the integration of central and peripheral functions at the homeostatic and behavioral level. Key Words: angiotensin [II.sub.1-7]; neurospecific protein S100b; serum albumin; hemodynamics; drinking behavior
ISSN:0007-4888