Effects of Histochrome on P53 Expression in Mouse Red Bone Marrow Cells in a Model of Chronic Stress

The clinical efficacy of the formulation Histochrome cannot be explained solely on the basis of its antioxidant properties. With the aim of identifying possible additional mechanisms of action of the medicinal substance (echinochrome A) in Histochrome, its effects on p53 expression were studied in b...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2014-06, Vol.48 (3), p.149-152
Main Authors: Kareva, E. N., Tikhonov, D. A., Mishchenko, N. P., Fedoreev, S. A., Shimanovskii, N. L.
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Gene expression
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Tumor proteins
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Summary:The clinical efficacy of the formulation Histochrome cannot be explained solely on the basis of its antioxidant properties. With the aim of identifying possible additional mechanisms of action of the medicinal substance (echinochrome A) in Histochrome, its effects on p53 expression were studied in bone marrow cells in SHK mice in a model of chronic stress. Echinochrome Aat a dose of 1 mg/kg (single daily i.p. doses for seven days prior of stress) normalized the level of p53 gene expression. The antioxidant formulation Histochrome had antistress properties in this experimental model in mice.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1067-x