Targeted delivery of cisplatin by connexin 43 vector nanogels to the focus of experimental glioma C6

The aim of this study was to create a nanocontainer conjugated with monoclonal antibodies to connexin 43 (Cx43) that is actively expressed at the periphery of C6 glioma and in the astroglia roll zone. Stable vector nanogels with high (up to 35%) cisplatin load were synthesized. The antitumor effects...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-08, Vol.157 (4), p.524
Main Authors: Nukolova, N.V, Baklaushev, V.P, Abakumova, T.O, Melnikov, P.A, Abakumov, M.A, Yusubalieva, G.M, Bychkov, D.A, Kabanov, A.V, Chekhonin, V.P
Format: Article
Language:English
Subjects:
Drug delivery systems
Drugs
Gliomas
Monoclonal antibodies
Vehicles
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Summary:The aim of this study was to create a nanocontainer conjugated with monoclonal antibodies to connexin 43 (Cx43) that is actively expressed at the periphery of C6 glioma and in the astroglia roll zone. Stable vector nanogels with high (up to 35%) cisplatin load were synthesized. The antitumor effects of Cx43-modified cisplatin-loaded nanogels, free cisplatin, and nonspecific drugs were carried out on C6 glioma model. Vector nanogels reduced systemic toxicity of cisplatin, effectively inhibited tumor growth, and significantly prolonged the lifespan of animals with experimental tumors. Key Words: cisplatin; nanogels; targeted delivery; monoclonal antibodies to connexin-43; brain tumors
ISSN:0007-4888