Content of IL-10 and [CD4.sup.+][CD210.sup.+] cells in mice with adjuvant arthritis before and after treatment with cryopreserved placental cells

We analyzed the serum level of IL-10, blood content of [CD4.sup.+][CD210.sup.+] cells, and expression of IL-10 receptors in adjuvant arthritis before and after treatment with native and cryopreserved placental cells. In animals with experimental adjuvant arthritis, a negative correlation was found b...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-09, Vol.157 (5), p.673
Main Authors: Lutsenko, E.D, Bondarovich, N.A, Goltsev, A.N
Format: Article
Language:English
Subjects:
Analysis
Arthritis
Drug therapy
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Summary:We analyzed the serum level of IL-10, blood content of [CD4.sup.+][CD210.sup.+] cells, and expression of IL-10 receptors in adjuvant arthritis before and after treatment with native and cryopreserved placental cells. In animals with experimental adjuvant arthritis, a negative correlation was found between the index of arthritis and IL-10 concentration (r=-0.7; p=0.03); in addition, a considerable decrease in the content of [CD4.sup.+][CD210.sup.+] cells and changes in the expression of IL-10 receptors on cells of the lymph nodes and spleen were demonstrated. After administration of cryopreserved DMSO-protected placental cells (in contrast to administration of cryopreserved propanedioxysacharol-protected cell suspension), the content of [CD4.sup.+][CD210.sup.+] cells in the spleen of animals with experimental adjuvant arthritis returned to normal. Key Words: adjuvant arthritis; cryopreservation; placenta; interleikin-10; [CD4.sup.+][CD210.sup.+] cells
ISSN:0007-4888
DOI:10.1007/s10517-014-2641-7