Maternal and foetal cardiovascular effects of the anaesthetic alfaxalone in 2-Hydroxypropyl-[beta]-cyclodextrin in the pregnant ewe

The objective of this study was to determine the pharmacodynamics effects of the anaesthetic alfaxalone in 2- hydroxypropyl-[beta]-cyclodextrin in pregnant sheep after the intravenous injection of a 2 mg/kg weight dose. Six pregnant Ripollesa sheep, weighing 471 [+ or -] 4.4 kg, were used. Twenty-fo...

Full description

Saved in:
Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.13
Main Authors: Andaluz, Anna, Santos, Laura, Garcia, Felix, Ferrer, Rosa I, Fresno, Laura, Moll, Xavier
Format: Article
Language:English
Subjects:
Anesthetics
Complications and side effects
Cyclodextrins
Dosage and administration
Ewes
Fetus
Growth
Health aspects
Pregnancy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this study was to determine the pharmacodynamics effects of the anaesthetic alfaxalone in 2- hydroxypropyl-[beta]-cyclodextrin in pregnant sheep after the intravenous injection of a 2 mg/kg weight dose. Six pregnant Ripollesa sheep, weighing 471 [+ or -] 4.4 kg, were used. Twenty-four hours after instrumentation, sheep were anaesthetized with intravenous alfaxalone in cyclodextrin. Time to standing from anaesthesia was 30.0 [+ or -] 10.81 min. Foetal heart rate increased significantly during the first 5 min after alfaxalone administration. Significant differences were observed in maternal diastolic arterial blood pressure between minute 10 and minutes 90,120,150,180,210, and 240. Significant differences were observed for foetal systolic arterial blood pressure between 5 and 30 min after alfaxalone administration. Significant differences in foetal pH were detected during the entire study period, whereas maternal pH returned to baseline values by 60 min after alfaxalone administration. The present study indicated that alfaxalone in 2-hydroxypropyl-[beta]-cyclodextrin administered as an intravenous bolus at 2 mg/kg body weight produced minimal adverse effects and an uneventful recovery from anaesthesia in pregnant sheep and their foetus.
ISSN:1537-744X
1537-744X
DOI:10.1155/2013/189843