Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice

Skin cancer is the most common malignancy in the world and also one of the major causes of death worldwide. The toxic environmental pollutant 7,12-dimethylbenz[a]anthracene (DMBA) is a skin-specific carcinogen. Tannic acid (TA) is reported to be effective against various types of chemical-induced to...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2015-01, Vol.399 (1-2), p.217-228
Main Authors: Majed, Ferial, Rashid, Summya, Khan, Abdul Quaiyoom, Nafees, Sana, Ali, Nemat, Ali, Rashid, Khan, Rehan, Hasan, Syed Kazim, Mehdi, Syed Jafar, Sultana, Sarwat
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene
Animals
Anticarcinogenic Agents - pharmacology
Anticarcinogenic Agents - therapeutic use
Antioxidants
Biochemistry
Biomedical and Life Sciences
Cardiology
Croton - chemistry
Cyclooxygenase 2 - metabolism
Disease Progression
Drug Evaluation, Preclinical
Enzymes
Female
Glutathione - metabolism
Health aspects
Hydrogen Peroxide - metabolism
Inflammation
Interleukin-6 - metabolism
Life Sciences
Lipid Peroxidation
Medical Biochemistry
Mice
Nitric Oxide Synthase Type II - metabolism
Oncology
Plant Oils
Proliferating Cell Nuclear Antigen - metabolism
Skin - drug effects
Skin - metabolism
Skin - pathology
Skin Neoplasms - chemically induced
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Tannins - pharmacology
Tannins - therapeutic use
Xanthine Oxidase - metabolism
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Summary:Skin cancer is the most common malignancy in the world and also one of the major causes of death worldwide. The toxic environmental pollutant 7,12-dimethylbenz[a]anthracene (DMBA) is a skin-specific carcinogen. Tannic acid (TA) is reported to be effective against various types of chemical-induced toxicities and carcinogenesis as well. In the present study, we have evaluated the therapeutic potential of tannic acid in DMBA + croton oil-induced skin cancer in Swiss albino mice. Protective effect of TA against skin cancer was evaluated in terms of antioxidant enzymes activities, lipid peroxidation, histopathological changes and expression of inflammation and early tumour markers. DMBA + croton oil causes depletion of antioxidant enzymes ( p  
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-014-2248-3